I was indifferent about seeing the Patpong area of Bangkok during my trip. But many people suggested that since it is a significant attraction in the city, I shouldn't miss out on the experience. So, on our last night before returning home, I went.
Contrary to what I had read, I did not see any "small girls with old men." Instead, I would describe these few blocks as an oversupply of strip clubs with cheesy "shows" in which the girls looked rather silly and bored.
The area itself seemed rather clean and modern. Nice restaurants and a lot of shopping. The market on these streets is a great place to pick up a few final souvenirs.
There seemed to be a mix of legit and questionable "massage parlors" and the girls in the strip clubs are not shy about cozying up to you, regardless of your gender. Most annoying is the guys on the sidewalk trying to get you into their club. Harmless, but annoying.
I still felt safe being in this more seedy district, and would go back, but probably not by myself.