If you are traveling by car, consider the Natchez Trace for part of your journey.
The Trace is a 442-miles national parkway, which runs between Natchez, Mississippi and Nashville, Tennessee, free of all commercialization, billboards and even towns. It is a peaceful drive through wooded areas and wide meadows. Speed limit is 50 mph and on the day we drove it, there was very little traffic. Be sure to pick up a map at one of the several visitor centers as it lists all the historic landmarks you can look for along the route.
You do not have to drive the entire parkway to experience this National treasure, you can jump on and off at any of the many exits along the way. Cost of this wonderful experience – just the price of gasoline.