This is secure and well situated in a city where you might not want to be wandering about too much at night. The area of the main railway station is always busy. Most long-distance coach companies have a terminus close to the station and the local buses mostly go from here (Sometimes you need to get a bus from here to the start of another one; e.g. for Monreale or Monte Pellegrino). Most local busstops are in the huge square outside the station.
Sraight across the square one of the largest roads is the well lit Roma and the hotel is just on the square at the third left turning. It can be seen from the main road; not that the outside looks like anything, but you use an answerphone to get in and then go up in a lift to a very clean, tidy, and comfortable pensio.
Limited English is spoken so a smattering of Italian is useful. However, it is a very friendly and helpful place. There are less than a dozen rooms so it is worth while phoning ahead. Toilets are separate but there are at least two and I never had to wait long.
Breakfast is not provided but there is no problem in just walking to the station.