The Barcelo Nervion is on the north bank of the river, just east of the glorious Zubi Zuri footbridge designed by Santiago Calatrava. The hotel has 7 floors and 348 rooms, with the larger suites facing the river. The hotel opened in 1971, was recently renovated, and is regarded as the largest hotel in the Basque country.
My standard room on a high floor did have a partial view of the Guggenheim, although I had to stand on a chair to enhance that particular view. Locals hanging laundry outside their balconies contributed to the quaintness of my room with a view. My room was comfortable and fairly spacious, though the bars of soap are small. The windows can be opened to provide some natural ventilation. Each room features a stocked minibar and a digitally-controlled thermostat.
The hotel lobby lounge was a bustling center of activity, as there was a large television monitor which periodically showed major international soccer matches. The locals were especially giddy when their beloved Athletic Bilbao defeated the national powerhouse Real Madrid, so drinks flowed freely in the lobby bar. Even if you are not interested in what is on the tube, you can take a look at local newspapers and tourist brochures here. Note that the three elevators are tiny, so if you do not want to take the stairs you may have to wait a bit if there is a large group staying the hotel.