For a number of years, my uncle and his family has been hosting an early Thanksgiving, and this was the first time Boyphoenix and I attended. It was also my first trip to the west coast.
We flew into San Francisco, picked up our rental car, and drove down Route 280 - just in time for the rush hour traffic, though things flowed smoothly.
Do plan a side trip to the Monterrey Peninsula, only a short drive away. While there, take in the sights and sounds of the sea lions sunning themselves on the rocks along the shore.
Best Way To Get Around:
It's best to drive, since things are fairly spread out.