When traveling through Denali, something that many people don’t realize is that you can’t drive through it with your own car, like you can in Yellowstone or Yosemite. In order to tour Denali, you’ll need a bus ticket. There are 2 basic ways to do this. You can either get a shuttle bus ticket, or you can book a tour bus. The first thing a person should do is decide how far you want to travel into the park and how much time you have. Check out http://www.reservedenali.com/shuttle_bus.php. If your priority is to see the wildlife and possibly Mt. McKinley, or "Denali" as many of the locals call it (on a clear day), in my opinion you want to go to at least Wonder Lake and even Kantishna. These are 86 miles and 91 miles long, respectively, and will take you nearly all day. The longer your ride, the greater your chances are to see different kinds of wildlife.
The next thing to determine is whether you want to stop and do any hiking/exploring or not. If you plan on doing some hiking and/or backcountry camping, you’ll definitely need one of the shuttle buses. The shuttle leaves from the Wilderness Access Center (this is also where you’ll go to pick up your reserved ticket.) The shuttles stop about once an hour for rest stops (at outhouses with antibacterial hand gel supplied), and also stop to pick up hikers and view wildlife. If you’re a hiker, you buy a shuttle bus to the point you eventually want to end up at. Along the way, if you want to stop and get off at any point, you let the bus driver know, and he will drop you off. When you want a ride to another spot along the road, you just go out to the main road and flag down one of the shuttle buses. The shuttle bus isn’t only for hikers, however. There are many people who ride it to the end and back, as we did. Although the bus drivers on the shuttles aren’t required to give any sort of guided tour, we found that the bus drivers do give somewhat of a narrated tour along the way in addition to answering relevant question. In order to travel this route, make sure you pack plenty of water, snacks, a lunch, bug spray, and a camera with a decent zoom lens (for the wildlife) since there are no places along the way to purchase these sorts of items.
If you prefer more of a structured tour, the other option is to buy a bus tour from one of the various tour companies that can be purchased through the park concessionaire. The guided bus tours come with a boxed lunch, and they also pick up and drop off from various locations inside the park. If you don’t have a car while there, this may be an important consideration. When we checked these out, they were running around $130/person to Kantishna.