How to summarize the town I came of age in, where I lived for 5 years as a student and grad student? In a word, unique. Ithaca is just a unique town, frequently cited by a major magazine as one of the best places in America to live.
It is home to a world-renowned Ivy League University (ahem, my alma mater, Cornell), a famous vegetarian restaurant (The Moosewood), the tallest waterfall in the Eastern US (including Niagara--Taughannock Falls) and all sorts of weird and unusual free-spirited people.
Quick Tips:
Attractions in and around Ithaca can be divided into a few categories:
Cornell (I'll start there since I'm an alum). You can walk around the huge campus, go up to the top of the belltower for an amazing view of Cayuga Lake and all of Ithaca, go to the Johnson Art Museum, walk around the Plantations, or attend a Cornell sporting event.
Collegetown--Just outside of the Cornell campus is the "student ghetto" where many students live in crowded apartments. There are a number of restaurants and stores to check out here.
Downtown/Commons--The Commons is a great place to gather, people-watch, shop, and eat.
Greater Ithaca region--Check out Buttermall Falls, Taughannock Falls, or Ithaca Falls, Stewart Park.
Finger Lakes region--Take a wine tour around Cayuga or Seneca Lake, visit the birthplace of women's rights in Seneca Falls, get in some NASCAR fun at Watkins Glen.
Depending on the amount of time you have to spend and the season, you can choose which to see. There is some amazing natural beauty in the Finger Lakes, and yes, some amazing wineries too, which you shouldn't miss.
However, if you're just in Ithaca for a day or weekend, I suggest spending some time on the commons and going to the Farmer's Market (seasonal). If you're with kids, check out the Sciencenter, a really fun interactive science museum. If you are into nature, be sure to go to one of the state parks such as Buttermilk Falls and try some hiking.Best Way To Get Around:
This solely depends on the weather. If it's nice out, you can walk around both Cornell University and the downtown area--I recommend starting at Cornell so you can walk DOWNHILL.
Same thing goes for biking--Ithaca is a bicycle town, but try to plan your voyage to avoid the huge hills.
If you're on foot or bike you can also hop on one of the many TCAT buses--Ithaca has a really wonderful bus system with signs announcing bus stops. Most rides you take will cost you .50, though there are 1- to 8-day passes available as well.
It's very easy to drive around Ithaca, and parking isn't too bad. Just make sure not to park on the Cornell campus without scrutinizing the signs...the parking police are notorious.
To get TO Ithaca, your options include the bus or car, with limited airline service to the Ithaca airport.