If you are there for pleasure, plan to stay in the Fisherman's Wharf area. There's so much to see and do all within walking distance and when you want to visit China Town, Downtown, or Union Square, the Cable Car is only a few steps away.
While downtown, make a trip to the top of the Bank of America building and have a cocktail at the Carnelian Room. The view of the city is incredible, especially at sunset.
Make sure to take the boat to Sausalito and spend the afternoon shopping and work up a big appetite for Angelino's Italian Restaurant. Rent a car for the day and drive down scenic Rt. 1 to Carmel. It is such a beautiful town, and the drive down is breathtaking.
Lunch at Little Napoli Bistro was unbelievably good and very reasonably priced. The staff couldn't do enough to make our luncheon memorable and enjoyable and they succeeded! Magnifico!! Alcatraz is very interesting and definitely worth a few hours out of your day. If you like wine, then book a trip to Napa or Sonoma for a day of wine tasting. Ceja Winery and Beuller's were two small wineries that were outstanding and had reasonable priced wines to ship home. Cakebread also gives a good tour and explains all the steps to making a tasty wine.
I could go on and on about the various things in SF, but one not to miss is the Buena Vista for their world-famous Irish coffee. Don't miss this one! It sits across the street from the turn-around for the Hyde Street Cable Car - great breakfast and the Irish coffees are super any time of day! We leave a little piece of our hearts in San Francisco every time we visit there!
Quick Tips:
Best Way To Get Around:
Cable cars at least once each visit. Taxis are readily available, and limos are reasonable to get you to and from the airport or wine country tours. Boat rides across the bay are fun.