Drinks with friends in any of a number of great little cafes and bars in the Gay Village along Canal street.
Grab a curry in Rusholme, home to every kind of Asian restaurant you could wish for.
Take a tram out to Old Trafford, Salford Quays or the new Lowry complex.
Visit Chinatown and see the famous imperial arch (although when I went it was under repair and covered in scaffolding!)
Shopping and plenty of it, but where do you start?
Drinking real Aussie beer on a night out in the new aussie pub Walkbout Inn.
Quick Tips:
Don't take a train to Manchester (or anywhere) until at least summer 2001 - the state of the railway network in the UK is awful right now - it has the potential to really spoil a great weekend away!
Best Way To Get Around:
Once in Manchester, public transport is excellent. Buses and trams run frequently from the centre out to all attractions and suburban areas. Check out the Centreline City Centre bus service for FREE, 7 days a week - runs every ten minutes, call 0161 2287811.
Walking around the city centre is also a viable option, although it is a big place so take a break and have a coffee or a pint of beer at every available opportunity!