If you've always wanted to go on a safari in Africa, northern Tanzania is the place you've probably been dreaming of. Arusha is lively town with a maze-like central market, great Indian food, and a number of nice hotels to meet all budgets. The best part of Arusha, however, is that it's a great base from which to see the sights of northern Tanzania. The must see places are the Sarengeti Plains, Kilimanjaro, and Ngorongoro Crater. Between the three you'll get your fix of wildlife, spectacular scenery, and... crowds.
I'd balance with some other less-traveled gems: Arusha National Park is home to Mount Meru, one of the most dramatic volcanoes around; Lake Mayara National Park is packed with wildlife; and Tarangire National Park is the place to go if you're dying to watch an elephant nuzzle up to a baobab tree.
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Renting a car would be ideal, but costs a fortune. Hitchiking can be unreliable. Buses can be murder. Depending on your safari agency's vehicle is simplest, but you do sacrifice a little freedom.