Prague attractions:
Charles Bridge, The Prague Castle and palace gardens, Old Town Square House at the Stone Bell, New Town, National Gallery: Veletrzni Palace, Sternberg Palace, and St. Georges Convent, National Museum and Antonin Dvorak Museum, Lobkovic Palace, National Technical Museum, Museum of Decorative Arts, Petrin View Tower, The Maze, The Powder Tower, The Municipal House, St. Nicholas Church, Vrtbovska garden, Bertramka (Mozart Museum), Church of Our Lady of Victory (The Prague Bambino), Old New Synagogue, Botanical Garden in Troja, Krizik Fountain, Jewish Town except Pinkas Synagogue, Bedrich Smetana Museum, Naprstek Museum, Troja Castle and garden, Wallenstein Garden, and the zoo in Troja.
The Slavic language is used, and English isn't common outside of hotels and a few restaurants/bars. Communication is accomplished through a combination of verbal and visual interaction.
Lala Restaurant in Pisek has really wonderful food.
Quick Tips:
When booking your hotel, try to get Parah 1 or 2 near the center of the city. The second digit of their postal code is the key, i.e. Parah 12 is Parah area 2. Book anywhere else, and your trip to downtown becomes farther away.
If you like beer, go for a Budweiser in this country. Budweiser here isn't the same company nor the same taste. Budweiser once tried to acquire the company in this country but, fortunately, failed. The company that brews from the U.S. has the slogan, "The King of Beers." The company slogan in the Czech Republic is "The Beer of Kings." Taste the difference--it is far superior.
Best Way To Get Around:
Getting around Prague via public transportation is great if you can decipher the Slavic language. Single 2 zone fare is CZK 12, and 24-hour pass fare is CZK 70. The underground metro stops running at midnight, and limited all-night trams and bus service are available.
Beware of Metro C Hlavni Nadrazi at nighttime, especially if you're by yourself at that station. I've been warned that gypsies are on the lookout for targets. It's best not to be by yourself there.