Admission=18,000L The hours are M-F 8:45-16:30 and Sat 8:45-13:45. Last entrance: 45 minutes prior to closing. Mondays are especially big days for tour groups to hit the museum. We were there on a Monday morning at 8:30 and waited 1 hour. On Tuesday some fellow travelers went and had no wait at 9:00. More info can be found at www.vatican.va
This is probably the most incredible museum I've ever seen. It is filled with everything from Egyptian artifacts to Rennaissance art. It has a very simple one-way system to move the thousands of daily visitors through in an organized manner. Most people visit to see the Sistine Chapel, but to rush to it would be a HUGE mistake! The quickest option would be a minimum of 2 hours. My wife and I spent 4 hours and we felt we moved rather quickly. This museum is too immense to try on your own. You will need a guidebook because what you can obtain at the museum is lacking in background information. I am a huge fan of Rick Steves, and his book 'Mona Winks' was fabulous for walking us through this massive museum. You can rent a CD-Rom wand for 8,000L
Some famous works are Hammurabi's Code, sculptures of Laocoon and Apollo Belvedere. Also the Belvedere Torso is on display. Michelangelo considered it his master and teacher. Raphael's School of Athens is on display (my personal favorite!). A hall of tapestries which are incredibly moving is prior to the Sistine Chapel and often overlooked. The Sistine Chapel cannot be summed up in words. Definitely worth the hype!
The Vatican Post is right before the exit, but can be accessed when you enter. It is much quicker than Italian post.
At the rear of the Sistine Chapel is a quick way to get to San Pietro. You have to act like you're with a tour group, but saves you some time. I don't know what you miss, but after the Sistine Chapel, you will probably be 'arted' out.