Tribeca is my favorite part of Manhattan and the Tribeca Grill is a mainstay of the neighborhood dining establishments. Several stars including Robert DeNiro and Mikhail Baryshnikov invested in the restaurant and it is reputed to be a popular place for stars to dine (although I have not seen anyone famous the four times I have eaten here).
The interior is a spacious, warehouse type area that is very well done and a nice backdrop for a nice meal.
The food has always been very solid, though not spectacular. I particularly enjoyed the lamb and every fish dish I ordered. An extensive wine list and lots of interesting menu items to choose from make this restaurant a good, safe choice if you are in the neighborhood.