Reserve your ticket ahead if you know what's good for you! We did, and were able to stride right up to the entrance and gain admission in about one minute flat. The price was 15,000 lire/person ($7.50) with a surcharge of $1.50 for the reservation. We also rented the audio guide in English, since the Uffizi is so large and has so many masterpieces. One audioguide with two listening devices (you have to love one another enough to stand close together) cost 12,000 lire ($6). A single audioguide cost 8,000 ($4). With the guide, we were able to cover the museum in about 2 hours and 45 minutes, including a break for espresso in the museum cafe.
This former office complex ("uffizi" means "offices" in Italian) houses some of the greatest masterpieces of Western art. The Byzantine collection is moving--look closely at the stunning detail work on the gold leafing.
The room featuring the Botticellis is quite crowded, as was the case six years ago. But don't let the crowd scare you off. Also study Botticelli's Annunciation in the room before that with his Venus and Primavera.
I particularly enjoyed Holbein's Portrait of Sir Richard Southwell, so realistic that you can see his shaving scars. The Uffizi's corridor grants a stunning view of the Arno and the Ponte Vecchio, but NO PHOTOS OF THE VIEW, as my husband learned from a guard.