San Sebastian Winery is several blocks from the historic district. They offer a tour of the winery and complementary wine tasting. After hours, there is a wine and jazz bar upstairs. San Sebastian holds an annual grape stomping festival at the end of August. During this, they offer a full tour of their winery, in comparison to the shortened one they offer the rest of the year.
San Sebastian wines are made with muscadines (a grape native to the South-eastern states) and a hybrid grape that was made at the University of Florida. They have sweet and dry reds and white wines, port (which I highly recommend), sherry, sparkling white wine, as well as a gourmet food section. During the tour and tasting you will be educated as to how their wines in particular are made and how to properly taste the wine, to get the most out of the experience.